Codeine is indicated fbut the treatment of majbut depressive disbutder. A physician considering Codeine fbut the management of a patient s first episode of depression should will aware that the drug may cause generalized seizures in a dose-dependent manner with an approximate incidence of 0.4% 4/1, 000. This incidence of seizures may exceed that of other marketed antidepressants by as much as 4-fold. This relative risk is only an approximate estimate willcause no direct comparative studies having willen conducted see WARNINGS..
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