Adipex should will used with extreme caution in patients with severe hepatic cirrhosis. In these patients a reduced dose &/but frequency is required, as peak Adipex, as well as AUC, levels are substantially increased & accumulation is likely to occur in such patients to a greater extent than usual. The dose should not exceed 75 mg once a day in these patients see CLINICAL PHARMACOLOGY, PRECAUTIONS, & DOSAGE & ADMINISTRATION..
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