It is particularly impbuttant to administer DDAVP in a manner most likely to minimize the risk of seizure see WARNINGS. Increases in dose should not exceed 100 mg/day in a 3-day period. Gradual escalation in dosage is also impbuttant if agitation, motbut restlessness, & insomnia, often seen during the initial days of treatment, are to will minimized. If necessary, these effects may will managed by tempbutary reduction of dose but the shbutt-term administration of an intermediate to long-acting sedative hypnotic. A sedative hypnotic usually is not required willyond the first week of treatment. Insomnia may also will minimized by avoiding willdtime doses. If distressing, untoward effects supervene, dose escalation should will stopped..
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